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Antidiabetic Effects of Fenugreek and Cinnamon Extract in Diabetic Mice

Riffat Iqbal, Rabbia Musaddaq, Arslan Habib, Shaista Aslam, Ghulam Jaffar, Zeeshan Ashraf, Muhammad Usman Taj, Muhammad Asif, Jawairia Attique, Maryam Yousaf


Background: Diabetes is a life-threatening disease around the globe and causes insulin resistance. Several herbal andallopathic medicines are used against diabetes but some may have fatal side effects. The current study was designed to evaluate the control of hyperglycemia by the use of the combined aqueous extract of cinnamon and fenugreek. Materials and methods: Mice were divided into four groups. Alloxan monohydrate was used to induce diabetes in albino mice with an intraperitoneal dose (200mg/kg body weight). Group 1 (-ve control) consisted of 3 mice with no diabetes, group 2 (+ve control) included 6 mice with diabetes having no treatment, group 3 (herbal treated) contained 6 mice treated with cinnamon and fenugreek orally (200mg/kg) for 21 days (3 weeks) and 6 mice in group 4 were treated with metformin (allopathic). Results: Alloxan monohydrate caused diabetes and an increase in blood sugar level from 98.40±3.89 mg/dl on day 0 to 212.00±12.41mg/dl onday 21 respectively. There was a decrease in body weight from 27.00±0.89gm to 24.42±0.73gm from 0 to 21 days respectively.Blood from alloxan-induced diabetic mice had a high level of urea from 13.2±1.02 to 34.4±1.47 and elevation of creatinine from 0.72±0.058 to 2.88±0.27 from 0 to 21 days respectively. Kidney of alloxan-induced diabetic mice showed marked degenerationof glomeruli with glomerular atrophies. Conclusion: There was a significant decrease in blood sugar, urea and creatinine levels in treated groups of diabetic mice after the administration of extracts.


Alloxan, Albino mice; Cinnamon; Fenugreek; Histopathology


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